Disruptive mutations in MITF also cause Tietz syndrome, which is characterized by depigmentation of the skin, hair, iris and severe hearing loss, and Waardenburg syndrome type 2A, which is characterized by patchy depigmentation of the skin and bi- or unilateral deafness in humans and mice [37, 40, 45]. This evidence concerns the gene MITF and Waardenburg syndrome type 2A.