In CAOV-3 cells, CXCL12 and its receptor CXCR4 stimulated the secretion of integrin β-1 and vascular endothelial growth factor-C (VEGF-C) [122], indicating the involvement of this receptor in the stimulation of tumor vasculature in ovarian cancer. The gene discussed is CXCR4; the disease is ovarian carcinoma.