Such debate has necessitated the use of genetically engineered mouse models (GEMMs) to trace the role of EMP in cancer progression, specifically the pancreatic epithelium conditional Kras/P53 mutant (PKCY) mice Lineage labelling of epithelial cells in this spontaneous PDAC model has allowed researchers to track these cells as they adopt mesenchymal properties and migrate away from the primary tumour into the circulation, seeding liver metastases [70]. This evidence concerns the gene KRAS and neoplasm.