Invasive regions of human carcinomas are typically characterised by the presence of tumour-derived, fibroblast-like cells expressing mesenchymal markers such as vimentin, fibronectin and N-cadherin, with decreased expression of epithelial adhesion molecule E-Cadherin and increased nuclear beta-catenin relative to surrounding cells [53,54,55,56,57]. The gene discussed is CDH1; the disease is neoplasm.