In a proteomic experiment, we demonstrated that early phases of coronary atherosclerosis at the stage of stable atherosclerotic plaques (lipidosis and fibrosis) show increased amounts of cytoskeletal proteins (actin, tropomyosin β chain, vimentin, keratin, tubulin β chain, and MAGP-4), SAP, and annexin 5. This evidence concerns the gene ANXA5 and lysosomal lipid storage disorder.