Moreover, treatment with sclerostin antibodies in human TNF transgenic mice with late stage inflammatory arthritis, lead to a great improvement in bone complications: in this study, the treatment reversed systemic and periarticular osteopenia, improved articular cartilage damage, blocked progression of bone erosion and, when combined with TNF inhibitors, it was also able to reverse and repair articular cartilage damage and cortical bone erosions [31]. Here, TNF is linked to Osteopenia.