SOX2 and cancer: With regards to known cancer drivers, 24 showed alterations, including the oral cell lineage transcription factors TP63 (amplified, 21.94%) and SOX2 (amplified, 20.97%), CDKN2A, CCND1 (amplified, 24.27%), PIK3CA (amplified, 20.97%) and EGFR (amplified, 10.67%) (Figure 3).