After analysing missense mutations and truncated mutations in oncogenes and tumour suppressors (results not shown), we have found that generally, in oncogenes, missense mutations are superior to truncated mutations but not in tumour suppressors, except from those more famous in HNSCC as CDKN2, FAT1 or PTEN. This evidence concerns the gene CDKN2A and head and neck squamous cell carcinoma.