It is known that the role of lncRNAs is closely associated with their localization in cells.13 For example, the cytoplasmic NF‐κB interacting long noncoding RNA (NKILA) inhibits metastasis in breast cancer.25 Zhang et al revealed that CCAT1 could serve as a scaffold in nucleus and as a molecular decoy for miR‐7 in cytoplasm in esophageal squamous cell carcinoma cells.26 Currently, we figured out that LINC01116 was predominantly distributed in the cytoplasm of NPC cells. The gene discussed is NFKB1; the disease is esophageal squamous cell carcinoma.