On the other hand, miR-155 was negatively associated with symptomatic asthma phenotype as well as with negative bronchodilation with symptoms that may be explained by the fact that this miRNA is able to regulate the Th2 inflammation through a downregulation of the secretion of IL-4, IL-5 and IL-13 by Th2 cells [48]. The gene discussed is IL4; the disease is asthma.