CXCL9 and CXCL10 are produced primarily by monocytes, dendritic cells and cancer cells and attract CD4+ T cells, CD8+ T cells and NK cells.45 IFN‐γ and type I interferons secreted by other recruited immune cells induce higher expression of these chemokines resulting in a positive amplification loop.46 The T and NK cells infiltrating BRAFi‐sensitive tumors arrive in a highly immunogenic milieu with high levels of proinflammatory cytokines, such as IL‐12, IL‐15 and IL‐18. This evidence concerns the gene CD4 and cancer.