The inhibitory molecules PD‐1 and TIM‐3 are upregulated upon T‐cell activation but sustained expression is considered a marker for T‐cell exhaustion but also marks exhausted NK cells.33 Indeed, these receptors were present on infiltrating T and NK cells in untreated tumors, however, BRAFi treatment resulted in a low expression of PD‐1 on NK cells and a low expression of TIM‐3 on T cells indicating that both cell types might be differentially inhibited in the tumor microenvironment. Here, PDCD1 is linked to neoplasm.