Further analysis indicated that the levels of TNF-α and IL-6 in serum and GN tissues of the rats that had been treated with Salidroside at a medium or high dose were comparable with that in the healthy group, but were significantly lower than that in the COPD group (P<0.01, P<0.001, Figure 3D,E). This evidence concerns the gene TNF and chronic obstructive pulmonary disease.