In a previous research in Western Mexico, we identified and association of the 7‐CATT and −173*C alleles with high disease activity in RA patients (Llamas‐Covarrubias et al., 2013); thereby, seems that these MIF polymorphisms are not associated with the risk of developing RA, however, they may be associated with the activity of the disease. Here, MIF is linked to rheumatoid arthritis.