CBLN1 and cancer: CER is not only an element of the membrane structure, but also a critical mediator of cellular functions, such as proliferation and apoptosis.21, 22, 23, 24 Disturbances regarding CERS and signaling have been discovered to be implicated in many sorts of cancers.22, 25, 26 As an influential member of the CERS family, dozens of studies have indicated that CERS6 is involved in cancers.