For the further investigation of the possible biological part of CERS6 plays in BC tumorigenesis, we upregulated CERS6 through using pcDNA‐CERS6 with vector as scramble control and knocked down CERS6 through using shCERS6#1, shCERS6#2, shCERS6#3 with shCtrl as scramble control. The gene discussed is CERS6; the disease is breast cancer.