Recently, soluble serum biomarkers, such as circulating cell‐free DNA, have been regarded as potential surrogates for predicting clinical outcomes in cancer patients.24, 25 However, no data on soluble TGF‐β (sTGF‐β) in unresectable pancreatic cancer or its association with prognosis and its dynamic changes during chemotherapy are available. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.