The study results are consistent with previous studies that show limited benefits with ICI retreatment.6, 7, 8, 9, 10, 11 However, certain factors positively predict the efficacy of ICI retreatment such as very high PD‐L1 expression (tumor proportion score, TPS ≥80%),8 favorable response to initial ICIs,6, 7 or radiotherapy before ICI retreatment.11 The fact that none of the patients presented with ≥50% TPS or a favorable response to initial anti‐PD‐L1 antibody treatment, could explain the poor response to subsequent anti‐PD‐1 antibodies in this study. Here, CD274 is linked to neoplasm.