SERPINE1 and thrombotic disease: The A/G variant of rs1799889 polymorphism is associated with a guanosine insertion at the −675 site of the PAI.15 Past pre‐clinical studies also demonstrated that the transcriptional activity of A allele was significantly higher than that of the G allele.16, 17 So theoretically, it is possible that carriers of the A allele were more prone to thrombotic disorders compared to carriers of the G allele.