Some data has shown that there are other factors decreasing immediate and long-term remission rates, such as: macroadenoma, dural or cavernous sinus invasion, postoperative eucortisolism (in the absence of preoperative or postoperative medical treatment) and absence of tumor on MRI or ACTH positive tumor in pathology [2, 52]. The gene discussed is POMC; the disease is neoplasm.