POMC and adenoma: A study by Batista et al. (72 children, follow-up 24–120 months) has shown the following factors associated with relapse: lack of histological confirmation of an adenoma, higher post-TSS serum cortisol or ACTH levels, a higher ACTH and cortisol responses to oCRH (CRH test performed after TSS), and glucocorticoid replacement for less than 6 months after surgery [36].