The expression level of JMJD3 was upregulated in neuroblasts, and JMJD3 deletion targeted and JMJD3 deletion impaired neuronal differentiation in both developing and adult mice impaired (Park et al. 2014); JMJD3 in the bronchopulmonary dysplasia (BPD) rat model, JMJD3 was found significantly reversed the hyperoxia-induced down-regulation of RUNX3, which was associated with pulmonary epithelial and vascular development in AT2 cells (Zhu et al. 2015). This evidence concerns the gene RUNX3 and bronchopulmonary dysplasia.