However, JMJD3 was also reported to play a carcinogenic role in other types of cancer in kidney, breast, prostate, skin, hemopoietic system, melanoma, renal cell carcinoma, Hodgkin’s lymphoma (HL), myelodysplastic syndrome (MDS), esophageal squamous cell carcinoma, ovarian cancer. This evidence concerns the gene KDM6B and esophageal squamous cell carcinoma.