JMJD3 was also found to promote expression of key genes involved in DNA replication and cell cycle phase transition, such as minichromosome maintenance deficient 4 (MCM4), heat shock protein 90-alpha 1 (HSP90AA1), flap endonuclease-1 (FEN1), MCM3, PCNA, and oncogene HOX genes to promote the progression of acute myeloid leukemia (AML) in mouse. The gene discussed is MCM4; the disease is acute myeloid leukemia.