This approach identified several genes that are associated with aging (ATP2B2, CAV3, CNTN3, CTNNA2, GRID2), inflammation (ATP2B2, CAV3, RAD18, KBTBD8), vascular permeability (SFXN5, RAD18) and anaphylaxis (CAV3, RAD18, CTNNA2, ATP2B2 and GRID2). Here, RAD18 is linked to anaphylaxis.