This approach identified several genes that are associated with aging (ATP2B2, CAV3, CNTN3, CTNNA2, GRID2), inflammation (ATP2B2, CAV3, RAD18, KBTBD8), vascular permeability (SFXN5, RAD18) and anaphylaxis (CAV3, RAD18, CTNNA2, ATP2B2 and GRID2). The gene discussed is CTNNA2; the disease is anaphylaxis.