B cells have been shown to secrete pro-tumorigenic factors (e.g., angiogenesis, tumor growth) and also to inhibit the antitumor immune response via cytokines.21–23 DCs are well known for their role in antigen presentations and in initiating an adaptive immune response.24 Tfh cells have been shown to favor an adaptive immune response via the B cell chemoattractant CXLC13 in breast cancer.25 Along with E-memory CD4 T cells, E-memory CD8 T cells possess a key role in the immune response and tumor infiltration. Here, CD4 is linked to breast cancer.