Interestingly, other genes were involved in tumor-suppressive activities, such as early growth response 1 (Egr1) and AP-1 subunit, which are both transcription factors implicated in tumor suppression.23,24 Egr1 regulates important tumor suppressors such as PTEN and p53 and upregulates tumor necrosis factor α. The gene discussed is PTEN; the disease is neoplasm.