ITGAM and neoplasm: Although the percentage of macrophages (CD45+, CD11b+, Gr1−) infiltrating into the tumors was not different between groups (Fig. 2a), treatment with LG268 significantly (p = 0.03) reduced the expression of CD206 by 65%, as evaluated by western blot in tumor lysates and immunohistochemistry of tumor sections (Fig. 2c, d).