RAW 264.7 cells stimulated with conditioned media from E18-14C-27C cells (tumor educated macrophages), showed significantly (p = 0.01 control vs. LG268 1000 nm) increased levels of PD-L1 upon treatment with LG268 at 1000 nm (control 55.2 ± 7.6% vs. LG268 1000 nm 72.0 ± 8.0%), but not with bexarotene (Fig. 7a–d). This evidence concerns the gene CD274 and neoplasm.