The immunosuppressive phenotype of MDSCs is associated with the expression of p-STAT1.34,35 Treatment with LG268 significantly (p = 0.02) reduced the expression of p-STAT1 by 80% in whole tumor lysates, as observed by western blotting (Fig. 2b) and confirmed by immunohistochemistry (Fig. 2d). This evidence concerns the gene STAT1 and neoplasm.