A larger effect was observed in familial cases (OR = 2.11; 95% CI = 1.43–3.32), for estrogen receptor-negative (ER-negative) breast cancer (OR = 2.37; 95% CI = 1.37–4.12) and for TNBC (OR = 3.56; 95% CI = 1.81–6.98).10 We showed an increased risk (OR = 3.93; 95% CI = 1.28–12.11) of the FANCM:c.5791 C > T (rs144567652) truncating variant using familial cases and controls. The gene discussed is FANCM; the disease is breast cancer.