Since 1562C/T gene polymorphism is reported diversely in different populations, and given to our results which are similar to an Italian study, 1562 T allele of MMP-9 promoter could be used as a biomarker in Iranians particularly for people who are more vulnerable to MS, like those who have family history of this disease or live under special environmental conditions such as industrial workplaces. This evidence concerns the gene MMP9 and myeloid sarcoma.