Our patient’s metastatic calvarial lesions were positive for synaptophysin, chromogranin, cytokeratin AE1/3, and ACTH, without Crook cells-effectively an identical morphology to the primary sellar lesion. However, the impact non-CNS metastatic disease has on mortality in PC patient remains unclear due to the rarity of the pathology and heterogeneity of the disease manifestations. The gene discussed is POMC; the disease is metastatic neoplasm.