AGAP1 and Global developmental delay: Both overexpression and downregulation of AGAP1 have been shown to affect neuronal endosomal trafficking and dendritic spine morphology in mouse primary neurons.31 Rare variants in AGAP1 have also been previously implicated in autism48 and suggested as a risk factor for schizophrenia.31 We demonstrated that AGAP1 morphant zebrafish have reduced startle and escape responses, reduced motility and developmental delay, further supporting a role for AGAP1 in neurodevelopment.