MMP2 and neoplasm: It is proposed that propranolol inhibits vasodilation via beta-receptors, which decreases blood flow to the lesion; blocks the release of proangiogenic factors (e.g., VEGF, bFGF, MMP-2, and MMP-9), thus limiting the growth of IH; and induces apoptosis in endothelial cells, favoring tumor remission (30).