In previous studies, several immune-related genes other than HLA have been linked to susceptibility to CM-SJS/TEN with SOCs, such as PTGER334, IKZF135, TSHZ235, IL-4R36, FasL37, IL-1338, and TLR34,34, suggesting that the combination of multiple gene polymorphisms and their interactions, including with HLA alleles, contributes strongly to the onset of CM-SJS/TEN with SOCs. This evidence concerns the gene CISH and cutaneous mastocytosis.