Similarly, genes included in regulation of apoptosis encoding such as TNF-receptor superfamily proteins (Tnf, Tnfrsf11b, Tnfrsf12a, Tnfrsf21), Fas cell surface death receptor (Fas), and caspases (Casp2, Casp6, Casp7) were higher in NASH compared to NASH + ISO. This evidence concerns the gene CASP6 and metabolic dysfunction-associated steatohepatitis.