PPARA and metabolic dysfunction-associated steatohepatitis: As expected, the essential gene expressions in fatty acid metabolism, steroid biosynthesis, and PPAR signaling pathway were invariably decreased in NASH + ISO, while the median change of gene expression level in fatty acid degradation was not different between groups although a slight decrease in genes associated with fatty acid degradation was observed in NASH + ISO group (Fig. 4b and Supplementary Dataset).