IL18 and pneumococcal meningitis: As demonstrated in our previous studies38,41, a nocturnal hyperactive phenotype was absent in both IFN-γ and IL-18 GKO mice that were cured of pneumococcal meningitis by CEFT – a phenomenon also observed in the present TLR2/4 GKO PM mice, notwithstanding a varying pattern of diurnal locomotion (less hypoactive in IFN-γ GKO, equally hypoactive in IL-18 GKO and more hypoactive in the current TLR2/4 GKO PM mice compared to the respective WT equivalents).