TP53 and breast carcinoma: This TP53 noncoding variant does neither appear to increase the risk for sporadic breast cancer nor for high-risk breast cancer (Supplementary Table 1);8 however, in this study, all breast cancer patients and the vast majority of the unaffected controls were genotyped for this variant by imputation8, which has relatively low accuracy for infrequent alleles like this TP53 variant26.