ATM and neoplasm: In vivo, when a combination of AZD7648 (75 mg kg−1 bid × 70 days) and olaparib (100 mg kg−1 qd × 70 days) was dosed to mice implanted with FaDu ATM KO xenografts, the treatment induced complete tumour regression, with 11 out of 11 mice showing no presence of tumour even 150 days after the combination treatment had stopped (Fig. 5c), whereas the combination treatment was not as efficacious in FaDu WT xenografts (Supplementary Fig. 8).