To this end, a range of small molecules have been identified including those refolding mutant p53 (e.g. PRIMA-19) or inhibiting proteasome dependent degradation of wild-type p53 (e.g., Reactivation of p53 and Induction of Tumor Apoptosis [RITA]10, Nutlin-3a11, SAR40583812). This evidence concerns the gene TP53 and neoplasm.