Yanaranop et al. [11] reported a specificity of 86% for HE4 and the receiver operating characteristic (ROC) area under the curve (AUC) demonstrating a better efficacy for HE4 alone compared to CA125 alone to diagnose ovarian cancer (0.893 and 0.865, respectively) [12]. This evidence concerns the gene MUC16 and ovarian carcinoma.