Moreover, the co-culturing of BMSC-EXOsi-PVT1 and ERG-overexpressing MNNG/HOS cells (MNNG/HOSAd-ERG) restored the defect of tumor malignancy caused by the co-culturing of BMSC-EXOsi-PVT1 and MNNG/HOS cells (Figure 4C). This evidence concerns the gene PVT1 and neoplasm.