The co-culturing of BMSC-EXO and ERG-interfering MNNG/HOS cells (MNNG/HOSsi-ERG) reduced the malignancy of osteosarcoma cells, while the co-culturing of BMSC-EXO and Ets-1-interfering MNNG/HOS cells (MNNG/HOSsi-Ets-1) did not negate such response (Figure 4B). Here, ERG is linked to osteosarcoma.