Since lncRNAs can be packaged in BMSC-derived exosomes and affect tumor growth [11, 17], we assumed that the upregulation of PVT1 in osteosarcoma cells is partly transported by BMSC-derived exosomes, and regulates downstream target expression thus promoting osteosarcoma growth and metastasis. The gene discussed is PVT1; the disease is osteosarcoma.