The different expressions of PVT1 were compared between BMSC-EXO and MNNG-EXO using qRT-PCR, and the result showed an elevator of PVT1 expression in BMSC- EXO (Figure 1C), suggesting that the upregulation of PVT1 in osteosarcoma cells may be derived from the transportation of BMSC-EXO. Here, PVT1 is linked to osteosarcoma.