In the study conducted by Jumbe et al [40], ERG was demonstrated to increase the bone matrix formation and promote osteosarcoma development via activating the transcription of TNSALP. Consistent with their studies, we also observed the upregulation of ERG in osteosarcoma cells and the pro-proliferating and pro-metastatic effect of ERG. The gene discussed is ALPL; the disease is osteosarcoma.