For three of these proteins, complexin-1 (CPLX1), complexin-2 (CPLX2) and synaptogyrin-1 (SYNGR1), the decreased expression in the outer two-thirds of the ML of the DG in AD was confirmed in another cohort of AD and control cases, using immunohistochemical staining. Here, CPLX2 is linked to Alzheimer disease.