For instance, IPA predicted that exocytosis was decreased in AD because of the expression profile of annexin-A1, calcium-dependent secretion activator 2 (CADPS2), CPLX2, neuronal calcium sensor-1 (NCS1), RAB3A, RAB3B, RAB3D, septin-5, SNAP25, SNAP29, syntaxin-1a, and visinin-like protein 1 (VSNL1) (Fig. 3A). This evidence concerns the gene RAB3A and Alzheimer disease.