Semi-quantitative analysis showed 28% decrease for CPLX1 (p = 0.005, Fig. 4A–4C), 12% decreased for CPLX2 (p = 0.048, Fig. 4D–4F), and 26% decrease for SYNGR1 (p = 0.005, Fig. 4G–4I) in AD compared with control. Here, CPLX2 is linked to Alzheimer disease.