TMEM207 and chronic myelogenous leukemia, BCR-ABL1 positive: Unexpectedly, a C57BL/6-Tg (ITF-TMEM207) mouse line (called line 16) developed a high incidence of spontaneous myeloproliferative disease-like phenotype, with histopathological features suggesting human MDS or CML, with precursor manifestations such as clonal hematopoiesis of indeterminate potential (CHIP), idiopathic cytopenia of undetermined potential (ICUS), and clonal cytopenia of undetermined significance (CCUS).