Interestingly, although CHIP has been reported to be associated with atherosclerotic heart disease (Jaiswal et al., 2017), even in this mouse, slight thickening of the inner elastic plate and increased numbers of smooth muscle cells of the aortic media were observed (Fig. 1L) compared with wild-type animals (Fig. 1M). This evidence concerns the gene STUB1 and carotid atherosclerosis.