To study the biological functions of TMEM207 in gastrointestinal tumors, we originally generated several C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines (Kito et al., 2014), in which murine TMEM207 is ectopically expressed under the regulatory control of the proximal promoter (truncated to approximately 200 bp) of the murine intestinal trefoil factor (ITF) gene (also known as Tff3). Here, TFF3 is linked to digestive system neoplasm.