KLK3 and Familial prostate cancer: Our recent review of 44 randomised controlled trials (RCTs) of dietary, nutrition and physical activity interventions suggest various dietary interventions (eg, low fat diet, soya and soya foods, selenium, lycopene or green tea) may reduce prostate cancer progression and mortality.2 However, many studies were assessed as being of low quality (with high or unclear risk of bias), underpowered, inadequately reported, of short duration or measuring surrogate outcomes, such as prostate-specific antigen doubling time, which has an uncertain relationship with prostate cancer progression.