HSF1 and neoplasm: Since interaction between 8q24.3 ploidy and tumor stage was present (p = 0.0016) but not between ploidy and HSF1 expression (p = 0.0976) (data not shown), model 3 (n = 4110) is additionally adjusted for interaction with tumor stage and confounding by HSF1-expression, resulting in doubled risks among those with gain (OR = 1.98, [1.22–3.21]) or amplification (OR = 2.19, [1.13–4.26])(Table 1).