EGFR and non-small cell lung carcinoma: As the first study aiming to evaluate EGFR-TKI plus VEGFR-TKI as a first-line therapy for advanced NSCLC, this ACTIVE phase III study will further assess the combination of apatinib and gefitinib as a new treatment approach for EGFR-mutant NSCLC in the first-line setting, with the aim to prolong survival and to delay the onset of resistance.