The JO25567 study evaluated bevacizumab plus erlotinib in advanced non-squamous NSCLC patients with activating EGFR mutations [21], showing that a PFS improvement of 6.3 months was achieved in the erlotinib plus bevacizumab group when compared to erlotinib monotherapy group (16.0 months vs. 9.7 months, hazard ratio [HR], 0.54, 95% confidence interval [CI] 0.36–0.79, P = 0.0015). Here, EGFR is linked to non-small cell lung carcinoma.