Potential drugs can be divided into PPAR-γ agonist, β3-AR agonist, insulin sensitizer, insulin, and lipase clearing factor stimulant, acting on signaling pathway including “PPAR signaling pathway”, “adipocytokine signaling pathway”, “insulin signaling pathway”, and “type II diabetes mellitus” (Table 2). Here, ADRB3 is linked to type 2 diabetes mellitus.