In addition, NOTCH2 and N2ICD levels were reduced in the poorly differentiated NPC cells (CNE-2) compared with the highly differentiated NPC cells (CNE-1) and in the highly metastatic NPC cells (5-8F) compared with the poorly metastatic NPC cells (6-10B) (P < 0.05; Fig. 1d). The gene discussed is NOTCH2; the disease is nasopharyngeal carcinoma.