NOTCH2 and neoplasm: Mice injected with oeNOTCH2 5-8F cells developed significantly fewer metastatic foci in the liver than mice injected with oeVec 5-8F cells with no alteration of primary tumor growth in the spleen (P < 0.05; Fig. 3e), indicating that NOTCH2 overexpression inhibits NPC cell metastasis in vivo.