However, compared with Ctrl CNE-2 cells, shNOTCH2 + LY294002 CNE-2 cells had significantly upregulated E-cadherin expression levels (P < 0.05) and significantly downregulated vimentin expression levels (P < 0.05), suggesting that AKT inhibitors block the EMT of NOTCH2-suppressed NPC cells (Fig. 5f). This evidence concerns the gene CDH1 and nasopharyngeal carcinoma.