According to ACMG/AMP 2015 guideline, the c.10740 + 7G > A SNP in USH2A gene was classified to uncertain significance (the evidence: PM2, this SNP at extremely low frequency which is below 0.5% in Exome Sequencing Project, 1000 Genomes and ExAC; PP4, patient’s phenotype and her family history are highly specific for Usher Syndrome with a single genetic etiology. This evidence concerns the gene USH2A and Usher syndrome.