HBCA infection with another flavivirus, Zika virus, is associated with only limited activation of immune cytokine/chemokine response, but ZIKV infection induces the highest upregulation of CXCL10, IL-6, 8, 12, and CCL5 (RANTES) [55], which corresponds with the observations in TBEV-infected HBCA. Here, IL6 is linked to Zika virus infectious disease.