The literature has demonstrated the presence of mild cognitive impairment (MCI) in patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS); evaluation of MoCA items further revealed selective reductions in visuospatial skills, executive function, attention and delayed memory, and MoCA scores were correlated significantly with serum levels of TNF-α [29]. This evidence concerns the gene TNF and obstructive sleep apnea syndrome.