CFTR and cystic fibrosis: Starting from the observation that the high ASL GLU concentration in human patients with CF [87] is responsible for the burst of the lung infection by pathogens [159], together with the highly expression of CFTR in the airway epithelium, it is reasonable to think that a CFTR defect leads to changes in the ASL lining the lungs, causing poor clearance of bacteria which ultimately exacerbates inflammation (see [39,160]).