The signaling mediated by cGMP, via several activated downstream effectors, including PKG (cGMP-dependent protein kinase), cyclic-nucleotide-gated ion channels and/or cyclic adenosine monophosphate (cAMP) pathways, has been reported to function as a tumor suppressor pathway, halting tumor growth, invasiveness, and angiogenesis [16,17,18,19,20]. Here, PRKG1 is linked to neoplasm.