However, as judged by our results, the solubilization and dilution procedures, as well as the constant supply of curcumin used in this research, were enough to efficiently synergize calcitriol antitumorigenic effects and to evoke antioxidant activity, as depicted by the reduced tumor growth and upregulation of liver GPx1 gene expression, respectively. The gene discussed is GPX1; the disease is neoplasm.