Others and we have shown that the promoter regions of miR-34a and 34b/c were frequently methylated in MM and that the expression of these miRNAs was increased by the demethylating agent decitabine, suggesting that p53 cannot induce the expression of these miRNAs and, consequently, cannot exert at least some of its tumor-suppressive functions through miR-34 [46,47,48,49,50]. Here, TP53 is linked to neoplasm.