Furthermore, miR-15a/16 has been found to inhibit cell proliferation in vitro by impairing the expression of CDC25A and cyclin D1 and D2, targeting the apoptosis inhibitory BCL-2, and inhibiting the AKT3 and NF-kB pathways that are thought to be important contributors to MM proliferation [16]. This evidence concerns the gene CCND1 and Miyoshi myopathy.