Silencing of histone deacetylase 4 (HDAC4) by short hairpin RNAs induced miR-29b expression through the hyperacetylation of its promoter, leading to the downregulation of miR-29b pro-survival target gene SP1, followed by the inhibition of MM cell survival and migration, and triggering of apoptosis and autophagy by MCL-1. This evidence concerns the gene HDAC4 and Miyoshi myopathy.