TNF and systemic lupus erythematosus: In previous studies it has been reported that the combination of fish oil (omega 3 and 6) with vitamin E has an impact on several SLE mediators, mice fed with fish oil and vitamin E showed a reduction in leukotriene, thromboxane and immunomodulatory cytokines such as IL-6, IL-10, IL-12 and TNF-α [7].