An imbalance of nutritional status and daily dietary intake have been implicated as risk factors for exacerbation of clinical manifestations of several autoimmune diseases such as rheumatoid arthritis (RA) and SLE, through triggering pathways involved in the expression of the inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) [7,8,9]. The gene discussed is TNF; the disease is autoimmune disease.