Using the LCMV cl13 infection protocol, IL-6-deficiency imparted a very modest 1.5-fold reduction of aged but not young IIo CD8+TE expansions that also mirrored a 1.4-fold decrease of the Io response; neither finding, however, proved significant (Fig 2D) suggesting an overall more limited contribution of IL-6 to differential young and old CD8+TM recall immunity. This evidence concerns the gene CD8A and infection.