As based on the experience with LFA-1 blockade in transplantation and autoimmunity [42, 43], and considering in particular the lower CD11a and CD54 expression of CD8+TN [9], we speculated that CD8+TM would be overall more resistant to LFA-1 blockade but that declining CD11a and CD54 levels by aging CD8+TM (Fig 4A/4B & S2 Fig) might render them again somewhat more susceptible to this intervention. The gene discussed is ITGB2; the disease is Autoimmunity.